5-Amino-1MQ

5-Amino-1MQ (5-Amino-1-Methylquinolinium Methyl Sulfate)

Description:
5-Amino-1MQ is a small-molecule compound that acts as a potent inhibitor of nicotinamide N-methyltransferase (NNMT)—an enzyme linked to cellular energy regulation, fat metabolism, and insulin sensitivity. By inhibiting NNMT activity, 5-Amino-1MQ helps increase NAD⁺ availability, thereby supporting enhanced mitochondrial function, fat oxidation, and metabolic efficiency. It has become a leading research compound in studies focused on obesity, metabolic disorders, and energy balance.

Key Benefits:

• Inhibits NNMT to elevate NAD⁺ and SAM (S-adenosylmethionine) levels

• Supports mitochondrial energy production and cellular metabolism

• Promotes fat loss and improved insulin sensitivity in research models

• Enhances muscle energy efficiency and endurance capacity

• Contributes to studies on obesity, metabolic health, and longevity

Mechanism of Action:
5-Amino-1MQ selectively inhibits NNMT, an enzyme responsible for methylating nicotinamide—a process that lowers NAD⁺ levels and disrupts energy metabolism. By blocking this pathway, 5-Amino-1MQ increases the intracellular pool of NAD⁺, a cofactor essential for sirtuin activation, mitochondrial biogenesis, and cellular repair. This results in improved metabolic rate, fat oxidation, and glucose utilization, making 5-Amino-1MQ a key compound in metabolic and anti-obesity research.

Molecular Formula: C11H12N2O4S
Molecular Weight: 284.29 g/mol
IUPAC Name: 5-Amino-1-methylquinolinium methyl sulfate
Purity: ≥98% (HPLC)
Form: Lyophilized powder or crystalline solid for research use

Storage:
Store at −20°C. Protect from light, heat, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days. Avoid repeated freeze–thaw cycles.

Disclaimer:
For laboratory research use only. Not for human consumption.