Activated AMPK

AICAR (Activated AMPK Peptide / 5-Aminoimidazole-4-carboxamide Ribonucleotide)

Description:
AICAR is a synthetic analog of adenosine monophosphate (AMP) that activates AMP-activated protein kinase (AMPK), a key cellular energy sensor responsible for regulating metabolism, glucose uptake, and fatty acid oxidation. By mimicking the effects of exercise at the molecular level, AICAR promotes enhanced energy metabolism, endurance, and mitochondrial efficiency. Research has identified its potential role in metabolic optimization, fat reduction, and endurance enhancement through AMPK pathway activation.

Key Benefits:

• Activates AMPK for improved cellular energy regulation

• Promotes fatty acid oxidation and glucose utilization

• Supports lean body composition and reduced adiposity

• Enhances mitochondrial performance and endurance capacity

• Mimics exercise-induced metabolic effects

Mechanism of Action:
AICAR enters the cell and is converted into ZMP (AICAR monophosphate), which acts as an AMP analog to activate AMPK. Once activated, AMPK triggers a metabolic cascade that increases glucose uptake, boosts fatty acid oxidation, and inhibits lipogenesis. This shift toward efficient energy utilization helps simulate the metabolic state of exercise, improving endurance and cellular repair. AICAR’s influence on mitochondrial biogenesis and oxidative balance has made it a key compound in studies of metabolic disorders, obesity, and performance adaptation.

Molecular Formula: C9H15N4O8P
Molecular Weight: 338.21 g/mol
CAS Number: 2627-69-2
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20°C. Protect from light and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days.

Disclaimer:
For laboratory research use only. Not for human consumption.