Bremelanotide

Bremelanotide (PT-141)

Description:
Bremelanotide, also known as PT-141, is a synthetic melanocortin receptor agonist derived from the α-melanocyte-stimulating hormone (α-MSH) analog Melanotan II. It is primarily studied for its ability to enhance sexual arousal and libido in both men and women through direct action on the central nervous system rather than hormonal or vascular pathways. In addition to its effects on sexual function, Bremelanotide has shown promise in energy regulation, mood support, and metabolic modulation research.

Key Benefits:

• Enhances sexual desire and arousal in men and women

• Works through central melanocortin pathways (non-hormonal mechanism)

• May support energy balance and mood regulation

• Promotes natural sexual function and performance

• Safe and short-acting profile with minimal systemic effects

Mechanism of Action:
Bremelanotide acts as a potent agonist at melanocortin receptors MC3R and MC4R located in the hypothalamus, stimulating neural pathways responsible for sexual arousal and motivation. Unlike phosphodiesterase inhibitors (e.g., sildenafil), Bremelanotide does not rely on vascular or hormonal systems but instead acts directly on central nervous system receptors to trigger desire and physiological readiness. Research has also identified possible roles in appetite control and energy regulation via melanocortin signaling.

Molecular Formula: C50H68N14O10
Molecular Weight: 1025.18 g/mol
Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20°C. Protect from heat, light, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days.

Disclaimer:
For laboratory research use only. Not for human consumption.