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Dermorphin

Price

$30.00

Dermorphin (Natural Heptapeptide Opioid Agonist)

Description:
Dermorphin is a naturally occurring heptapeptide opioid originally isolated from the skin of South American Phyllomedusa frog species. It exhibits extraordinarily high affinity and selectivity for μ-opioid receptors, showing up to 40 times greater potency than morphine in receptor binding studies, yet with reduced tolerance development. Due to its unique structure and blood–brain barrier permeability, Dermorphin is widely studied for its potential in pain modulation, neurochemistry, and receptor selectivity research.

Key Benefits:

  • Highly potent μ-opioid receptor agonist

  • Demonstrates strong analgesic effects in animal models

  • Reduced tolerance and side effects compared to morphine

  • Useful for receptor mapping and neuropharmacology studies

  • Supports research on pain, addiction, and neuroreceptor signaling

Mechanism of Action:
Dermorphin binds selectively to μ-opioid receptors (MOR) in the central and peripheral nervous system, activating G-protein–coupled pathways that inhibit adenylate cyclase and reduce neuronal excitability. This results in suppressed pain signaling and enhanced dopaminergic balance. Its unusual structure, containing a D-alanine residue at position 2, increases receptor binding stability and biological half-life, making Dermorphin an exceptional model compound for opioid receptor research.

Molecular Formula: C40H50N8O10
Molecular Weight: 802.87 g/mol
Sequence: Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20°C. Protect from light, heat, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days. Avoid repeated freeze–thaw cycles.

Disclaimer:
For laboratory research use only. Not for human consumption.

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