FOXO4

FOXO4-DRI (Forkhead Box O4 D-Retro Inverso Peptide)

Description:
FOXO4-DRI is a synthetic D-retro inverso peptide designed to selectively disrupt the interaction between FOXO4(Forkhead Box O4 transcription factor) and p53, a key regulator of cellular senescence and apoptosis. By blocking this interaction, FOXO4-DRI promotes the selective clearance of senescent cells, thereby supporting cellular rejuvenation, tissue regeneration, and longevity research. It represents one of the most advanced investigational compounds in the field of senolytic therapy and anti-aging biomedicine.

Key Benefits:

• Selectively targets and removes senescent (aging) cells

• Promotes cellular regeneration and tissue rejuvenation

• Enhances mitochondrial function and metabolic efficiency

• Supports longevity, vitality, and anti-aging research

• Reduces inflammation and oxidative stress associated with aging

Mechanism of Action:
FOXO4-DRI is a D-amino acid–based peptide engineered to resist enzymatic degradation and maintain bioactivity. It competitively inhibits the interaction between FOXO4 and p53, preventing p53 from remaining trapped in senescent cells. This allows for the natural apoptotic clearance of dysfunctional cells, reducing the secretion of inflammatory cytokines (SASP factors) and restoring healthy tissue function. Research indicates that FOXO4-DRI acts as a senolytic modulator, offering a unique approach to reversing aspects of cellular aging and promoting regenerative health.

Molecular Formula: C203H314N56O61S
Molecular Weight: ~4470.2 g/mol
Sequence: D-Retro Inverso form of Ac-Ser-Arg-Asn-Arg-Gly-Gln-Asn-Cys-Ala-Thr-Thr-Glu-Lys-Ala-Phe
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20°C. Protect from heat, light, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days. Avoid repeated freeze–thaw cycles.

Disclaimer:
For laboratory research use only. Not for human consumption.