GDF-8

GDF-8 (Myostatin / Growth Differentiation Factor-8)

Description:
GDF-8, commonly known as Myostatin, is a naturally occurring myokine belonging to the transforming growth factor-beta (TGF-β) superfamily. It functions as a negative regulator of skeletal muscle growth, controlling muscle cell proliferation and differentiation. Research on GDF-8 has demonstrated that inhibition or modulation of Myostatin activity can significantly increase muscle mass, strength, and regenerative capacity — making it a primary target in studies of muscle-wasting diseases, sarcopenia, and regenerative medicine.

Key Benefits:

• Regulates skeletal muscle mass and cellular differentiation

• Key target for muscle growth and regeneration research

• Plays a critical role in sarcopenia and muscle atrophy models

• Supports studies on myostatin inhibition and metabolic control

• Influences the balance of lean tissue development and adiposity

Mechanism of Action:
GDF-8 is synthesized and secreted by skeletal muscle cells as an inactive precursor, which is later cleaved to produce the bioactive mature dimer. Once active, it binds to Activin Type II receptors (ActRIIA and ActRIIB), triggering SMAD2/3 signaling that suppresses myoblast proliferation and differentiation. This process limits excessive muscle growth and maintains muscle tissue homeostasis. Research focusing on myostatin inhibitors—such as Follistatin, ACE-031, and GDF-11 modulators—has shown promising results in reversing muscle loss and promoting hypertrophy.

Molecular Formula: Variable (glycoprotein structure; dimeric form)
Molecular Weight: ~25 kDa (mature peptide dimer)
Family: TGF-β Superfamily Cytokine
Purity: ≥98% (HPLC / SDS-PAGE verified)
Form: Lyophilized protein powder for reconstitution

Storage:
Store at −20°C. Protect from heat, light, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days. Avoid repeated freeze–thaw cycles.

Disclaimer:
For laboratory research use only. Not for human consumption.