Sermorelin Acetate

Sermorelin Acetate (GRF 1–29 / Growth Hormone–Releasing Hormone Analog)

Description:
Sermorelin Acetate is a synthetic growth hormone–releasing hormone (GHRH) analog consisting of the first 29 amino acids of endogenous GHRH — the biologically active segment responsible for stimulating natural growth hormone (GH) secretion from the pituitary gland. This peptide is widely used in research related to growth hormone regulation, anti-aging, and metabolic optimization, offering a natural method of enhancing GH and IGF-1 production without exogenous hormone administration.

Key Benefits:

• Stimulates natural growth hormone and IGF-1 secretion

• Supports lean muscle development and cellular regeneration

• Enhances fat metabolism and energy balance

• Promotes better sleep, recovery, and cognitive clarity

• Preserves endogenous pituitary function and hormonal rhythm

Mechanism of Action:
Sermorelin binds to GHRH receptors on somatotroph cells in the anterior pituitary gland, activating the adenylate cyclase pathway and promoting the pulsatile release of GH. This, in turn, stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which mediates the regenerative and anabolic effects associated with growth hormone. Because Sermorelin works upstream in the GH axis, it maintains feedback regulation, preventing the desensitization or suppression associated with synthetic GH use.

Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.9 g/mol
Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20°C. Protect from heat, light, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days. Avoid repeated freeze–thaw cycles.

Disclaimer:
For laboratory research use only. Not for human consumption.