SS-31

SS-31 (Elamipretide / MTP-131 / Szeto–Schiller Peptide-31)

Description:
SS-31, also known as Elamipretide or MTP-131, is a mitochondria-targeting tetrapeptide designed to selectively bind to cardiolipin, a key phospholipid in the inner mitochondrial membrane. By stabilizing mitochondrial structure and function, SS-31 has been shown to reduce oxidative stress, enhance ATP production, and protect cells from mitochondrial dysfunction. It is widely studied in fields related to aging, neuroprotection, cardiovascular health, and metabolic restoration.

Key Benefits:

• Protects mitochondria and improves cellular energy efficiency

• Reduces oxidative stress and free radical damage

• Enhances ATP production and mitochondrial membrane stability

• Supports heart, brain, and muscle function under stress

• Promotes cellular longevity and recovery from mitochondrial injury

Mechanism of Action:
SS-31 penetrates the inner mitochondrial membrane and binds selectively to cardiolipin, a phospholipid critical for mitochondrial bioenergetics. This binding stabilizes the electron transport chain, reducing electron leak and reactive oxygen species (ROS) generation. By maintaining mitochondrial integrity and improving energy output, SS-31 helps restore metabolic balance and prevent apoptosis under stress conditions such as ischemia, neurodegeneration, or age-related decline.

Molecular Formula: C32H49N9O5
Molecular Weight: 639.8 g/mol
Sequence: D-Arg-Dmt-Lys-Phe-NH₂
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20°C. Protect from light, heat, and moisture. Once reconstituted, refrigerate (2–8°C) and use within 30 days.

Disclaimer:
For laboratory research use only. Not for human consumption.