Triptorelin

Triptorelin Acetate (Gonadotropin-Releasing Hormone Analog / LHRH Agonist Peptide)

Description:
Triptorelin is a synthetic decapeptide analog of Gonadotropin-Releasing Hormone (GnRH), also known as Luteinizing Hormone-Releasing Hormone (LHRH). It acts as a potent agonist of the GnRH receptor, stimulating the controlled release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. Prolonged exposure results in downregulation of gonadotropin secretion, making Triptorelin an important tool in research focused on endocrine regulation, reproductive biology, and hormone-dependent conditions.

Key Benefits:

• Modulates LH and FSH secretion through GnRH receptor signaling

• Supports research on hormone suppression and regulation

• Models pituitary-gonadal axis function in reproductive studies

• Used in experimental endocrinology, oncology, and fertility control studies

• Demonstrates potent and reversible desensitization effects on GnRH pathways

Mechanism of Action:
Triptorelin mimics natural GnRH, binding with high affinity to pituitary GnRH receptors, initially triggering a transient increase in LH and FSH secretion. Continuous administration leads to receptor desensitization and downregulation, resulting in suppressed gonadotropin and sex steroid hormone production. This dual-phase response allows precise control of testosterone and estrogen synthesis, making it a key peptide for neuroendocrine and reproductive research models.

Molecular Formula: C64H82N18O13
Molecular Weight: 1311.45 g/mol
Sequence: pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂
Purity: ≥98% (HPLC)
Form: Lyophilized powder for reconstitution

Storage:
Store at −20 °C. Protect from heat, light, and moisture. Once reconstituted, refrigerate (2–8 °C) and use within 30 days. Avoid repeated freeze–thaw cycles.

Disclaimer:
For laboratory research use only. Not for human consumption.